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A C-type lectin (CLEC) is a type of carbohydrate-binding protein domain known as a lectin. The C-type designation is from their requirement for calcium for binding. Proteins that contain C-type lectin domains have a diverse range of functions including cell-cell adhesion, immune response to pathogens and apoptosis. ==Classification== Drickamer ''et al''. classified C-type lectins into 7 subgroups (I to VII) based on the order of the various protein domains in each protein. This classification was subsequently updated in 2002, leading to seven additional groups (VIII to XIV). Most recently, three further subgroups were added (XV to XVII).〔 CLECs include: * CLEC1A, CLEC1B * CLEC2A, CLEC2B, CD69 (CLEC2C), CLEC2D, CLEC2L * CLEC3A, CLEC3B * CLEC4A, CLEC4C, CLEC4D, CLEC4E, CLEC4F, CLEC4G, ASGR1 (CLEC4H1), ASGR2 (CLEC4H2), FCER2 (CLEC4J), CD207 (CLEC4K), CD209 (CLEC4L), CLEC4M * CLEC5A * CLEC6A * CLEC7A * OLR1 (CLEC8A) * CLEC9A * CLEC10A * CLEC11A * CLEC12A, CLEC12B * CD302 (CLEC13A), LY75 (CLEC13B), PLA2R1 (CLEC13C), MRC1 (CLEC13D), MRC2 (CLEC13E) * CLEC14A * CLEC16A * CLEC17A The "NK Cell lectin-like receptors" are a very closely related group: * KLRA1 * KLRB1 (CLEC5B) * KLRC1, KLRC2, KLRC3, KLRC4 * KLRD1 * KLRF1 (CLEC5C) * KLRG1 (CLEC15A), KLRG2 (CLEC15B) * KLRK1 Additional proteins containing this domain include: * AGC1; ATRNL1 * BCAN * CD248; CD72; CD93; CHODL; CL-K1-Ia; CL-K1-Ib; CL-K1-Ic; CLECSF5; COLEC10; COLEC11; COLEC12; CSPG3 * FCER2; FREM1; HBXBP; * LAYN; LOC348174; LOC728276 * MAFA; MBL2; MGC34761; MICL; MRC1L1 * OLR1 * PAP; PKD1; PKD1L2; PLA2R1; PRG2; PRG3 * REG1A; REG1B; REG3A; REG3G; REG4 * SELE; SELL; SELP; SFTPA1; SFTPA2; SFTPA2B; SFTPD; SRCL * THBD * VCAN 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「C-type lectin」の詳細全文を読む スポンサード リンク
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